Pharmacokinetics:

Loratadine is rapidly absorbed from the gastrointestinal tract after oral doses, peak plasma concentrations being attained in about 1 hour. Bioavailability is increased and time to peak plasma concentration is delayed when taken with food. Loratadine undergoes extensive metabolism. The major metabolite, desloratadine, has potent antihistaminic activity. Reported mean elimination half-lives for loratadine and desloratadine are 8.4 and 28 hours, respectively. Loratadine and its metabolites have been detected in breast milk, but do not appear to cross the blood-brain barrier to a significant extent. Most of a dose is excreted equally in the urine and feces, mainly in the form of metabolites.

Indications:

It is used in the symptomatic relief of allergic conditions including rhinitis and chronic urticaria. It is also used with a decongestant such as pseudoephedrine sulfate.